U 4.kolu Caruana je savladao Swiercza i preuzeo vođstvo na turniru od Mishre koji je izgubio od Niemanna.
Posle 4. kola Caruana je u vođstvu sa 3 poena, a pola poena manje imaju Mishra, Shankland i Niemann.
| Rezultati 4. Kola (8.oktobar 2023) | ||||||
| Caruana, Fabiano | – Swiercz, Dariusz | 1-0 | 80 | C50 | Giuoco Piano | |
| Shankland, Sam | – So, Wesley | ½-½ | 59 | D35 | QGD Exchange | |
| Mishra, Abhimanyu | – Niemann, Hans Moke | 0-1 | 53 | B31 | Sicilian Rossolimo | |
| Aronian, Levon | – Robson, Ray | ½-½ | 38 | C50 | Giuoco Piano | |
| Sevian, Samuel | – Dominguez Perez, Leinier | ½-½ | 20 | C50 | Giuoco Piano | |
| Xiong, Jeffery | – Tang, Andrew | ½-½ | 34 | D02 | Queen’s Pawn Game | |
Stanje posle 4.kola
| 1. | Caruana, Fabiano | g | USA | 2786 | 3 |
| 2. | Niemann, Hans Moke | g | USA | 2667 | 2½ |
| 3. | Shankland, Sam | g | USA | 2698 | 2½ |
| 4. | Mishra, Abhimanyu | g | USA | 2592 | 2½ |
| 5. | Dominguez Perez, Leinier | g | USA | 2745 | 2 |
| 6. | So, Wesley | g | USA | 2753 | 2 |
| 7. | Aronian, Levon | g | USA | 2742 | 2 |
| 8. | Sevian, Samuel | g | USA | 2698 | 2 |
| 9. | Swiercz, Dariusz | g | USA | 2620 | 1½ |
| 10. | Xiong, Jeffery | g | USA | 2693 | 1½ |
| 11. | Tang, Andrew | g | USA | 2496 | 1½ |
| 12. | Robson, Ray | g | USA | 2699 | 1 |
Caruana,Fabiano (2786) – Swiercz,Dariusz (2620) [C50]
ch-USA 2023 Saint Louis USA (4.4), 08.10.2023
1.e4 e5 2.Nf3 Nc6 3.Bc4 Nf6 4.d3 Bc5 5.0–0 d6 6.c3 a6 7.a4 h6 8.Nbd2 0–0 9.h3 a5 10.Re1 Be6 11.b3 Re8 12.Bb5 Bd7 13.Nf1 Nb8 14.Bxd7 Nbxd7 15.Ne3 Bxe3 16.Bxe3 d5 17.exd5 Nxd5 18.Bd2 c5 19.Qc2 Qc7 20.Re2 Re6 21.Rae1 Rae8 22.Qb1 N7f6 23.Nh4 b6 24.Nf5 Qd7 25.Nh4 Nh5 26.g3 Nhf6 27.Nf3 R6e7 28.Rxe5 Rxe5 29.Rxe5 Rxe5 30.Nxe5 Qxh3 31.Qd1 Qf5 32.Qe2 Qe6 33.Qe1 Qf5 34.Kg2 h5 35.c4 Nc7 36.Qe2 Ne6 37.Nf3 Kf8 38.Bc3 g5 39.Nd2 h4 40.Ne4 Nxe4 41.dxe4 Qh7 42.Qg4 hxg3 43.fxg3 Ke7 44.Qf3 Qg6 45.Qd3 Qh5 46.Be5 Ke8 47.Kg1 Qg4 48.Bf6 Kf8 49.Kf2 Kg8 50.Qd5 Qh5 51.Qa8+ Kh7 52.Qh8+ Kg6 53.Qxh5+ Kxh5 54.Be5 Kg4 55.Bb8 f5 56.exf5 Kxf5 57.Ba7 Nd4 58.Bxb6 Nxb3 59.Ke3 g4 60.Bc7 Ke6 61.Ke4 Nd2+ 62.Kd3 Nb3 63.Bf4 Kf5 64.Be3 Ke5 65.Bh6 Kf5 66.Bg7 Nc1+ 67.Kd2 Nb3+ 68.Ke3 Kg6 69.Bb2 Kf5
70.Bc3 Kg5 71.Ke4 Kg6 72.Kf4 Kh5 73.Kf5 Nc1 74.Bxa5 Ne2 75.Bc7 Nd4+ 76.Ke4 Nc6 77.Bd6 Na5 78.Kd5 Kg6 79.Bxc5 Kf5 80.Bb6 1–0
Mishra,Abhimanyu (2592) – Niemann,Hans Moke (2667) [B31]
ch-USA 2023 Saint Louis USA (4.6), 08.10.2023
1.e4 c5 2.Nf3 Nc6 3.Bb5 g6 4.0–0 Bg7 5.c3 Nf6 6.Re1 0–0 7.d4 d5 8.e5 Ne4 9.Bxc6 bxc6 10.Be3 Qb6 11.Qc1 c4 12.Nbd2 Nxd2 13.Nxd2 Bf5 14.b3 Bd3 15.h4 h5 16.Bg5 Rfe8 17.bxc4 dxc4 18.Ne4 Bxe4 19.Rxe4 Rab8 20.Re2 Qa5 21.Qe3 Qd5 22.Rae1 Qe6 23.Qe4 Rb5 24.f3 Qd5 25.Qf4 c5 26.dxc5 Qxc5+ 27.Qe3 Rc8 28.Qxc5 Rcxc5 29.e6 fxe6 30.Re4 Bxc3 31.Rc1 Be5 32.Rexc4 Rxc4 33.Rxc4
33…Bg3 34.Kf1 Rb1+ 35.Bc1 Ra1 36.a4 Bxh4 37.Ke2 Ra2+ 38.Bd2 Bg5 39.f4 Bh6 40.Kd3 e5 41.g3 exf4 42.gxf4
42…e5 43.Rc8+ Kf7 44.Rc7+ Ke6 45.Rxa7 exf4 46.Ra6+ Kf5 47.Ra5+ Kg4 48.Ra6 h4 49.Rxg6+ Bg5 50.Bb4 f3 51.Bc5
51…h3 52.Be7 f2 53.Rxg5+ Kf4 0–1